Molecular understanding of drug interactions suggests pathway to better malaria treatments *By Jeannie Kever* Researchers from the University of Houston and the Université libre de Bruxelles published findings in *Nature* demonstrating for the first time at the molecular level what happens when two antimalarial compounds that each inhibit hematin crystal growth are combined. The results were counterintuitive. Rather than acting synergistically or additively, many drug pairs exhibited antagonistic cooperation—actually reducing each other’s effectiveness. Using atomic force microscopy and computational modeling, the team showed that when two drugs attack crystallization through different mechanisms, they can interfere with each other at the crystal […]