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Differential Responses of Amyloid‐β 42 Aggregates to Resveratrol
Advanced Biology, 10 (2026)
DOI: 10.1002/adbi.202500586 -
Modifiers Regulate Crystal Morphology by Generating Lattice Defects
Crystal Growth & Design, 26, pp. 934-943 (2026)
DOI: 10.1021/acs.cgd.5c01526
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Antagonistic cooperativity between crystal growth modifiers
Nature, 577, pp. 497–501 (2020)
DOI: 10.1038/s41586-019-1918-4
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Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapies
Science Advances, 5, pp. eaax3905 (2019)
DOI: 10.1126/sciadv.aax3905 -
Crystallization tracked atom by atom
Nature, 570, pp. 450–452 (2019)
DOI: 10.1038/d41586-019-01965-2 -
Steady, Symmetric, and Reversible Growth and Dissolution of Individual Amyloid-β Fibrils
ACS Chemical Neuroscience, 10, pp. 2967–2976 (2019)
DOI: 10.1021/acschemneuro.9b00179 -
Anomalous Dense Liquid Condensates Host the Nucleation of Tumor Suppressor p53 Fibrils
iScience, 12, pp. 342–355 (2019)
DOI: 10.1016/j.isci.2019.01.027
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Structuring of Organic Solvents at Solid Interfaces and Ramifications for Antimalarial Adsorption on β-Hematin Crystals
ACS Applied Materials & Interfaces, 10, pp. 29288–29298 (2018)
DOI: 10.1021/acsami.8b08579 -
Weakly-bound Dimers that Underlie the Crystal Nucleation Precursors in Lysozyme Solutions
bioRxiv (2018)
DOI: 10.1101/275222
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Mesoscopic Solute-Rich Clusters in Olanzapine Solutions
Crystal Growth & Design, 17, pp. 6668–6676 (2017)
DOI: 10.1021/acs.cgd.7b01299 -
Early Onset of Kinetic Roughening due to a Finite Step Width in Hematin Crystallization
Physical Review Letters, 119, pp. 198101 (2017)
DOI: 10.1103/PhysRevLett.119.198101 -
Deconstructing Quinoline-Class Antimalarials to Identify Fundamental Physicochemical Properties of Beta-Hematin Crystal Growth Inhibitors
Chemistry – A European Journal, 23, pp. 13638–13647 (2017)
DOI: 10.1002/chem.201702251 -
Polymorphism of Lysozyme Condensates
The Journal of Physical Chemistry B, 121, pp. 9091–9101 (2017)
DOI: 10.1021/acs.jpcb.7b05425 -
Differential dynamic microscopy of bidisperse colloidal suspensions
npj Microgravity, 3, pp. 21 (2017)
DOI: 10.1038/s41526-017-0027-7 -
Antimalarials inhibit hematin crystallization by unique drug-surface site interactions
Proceedings of the National Academy of Sciences, 114, pp. 7531–7536 (2017)
DOI: 10.1073/pnas.1700125114 -
Shear flow suppresses the volume of the protein-rich clusters in lysozyme solutions
Journal of Crystal Growth (2017)
DOI: 10.1016/j.jcrysgro.2016.12.080 -
Two types of amorphous protein particles facilitate crystal nucleation
Proceedings of the National Academy of Sciences, 114, pp. 2154–2159 (2017)
DOI: 10.1073/pnas.1606948114 -
Biomimetic assay for hematin crystallization inhibitors: a new platform to screen antimalarial drugs
Crystal Growth & Design, 17, pp. 197–206 (2017)
DOI: 10.1021/acs.cgd.6b01424
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Confocal depolarized dynamic light scattering: a technique for complex fluids
Medical Research Archives, 2 (2016)
DOI: 10.18103/mra.v2i2.407 -
Characterization of the diffusive dynamics of particles with time-dependent asymmetric microscopy intensity profiles
Soft Matter, 12, pp. 6926–6936 (2016)
DOI: 10.1039/C6SM00946H -
Protein conformational flexibility enables the formation of dense liquid clusters: Tests Using Solution Shear
Journal of Physical Chemistry Letters, 7, pp. 2339–2345 (2016)
DOI: 10.1021/acs.jpclett.6b00822 -
Multi-responsive Hybrid Particles: Thermo-, pH-, Photo-, and Magneto-responsive Magnetic Hydrogel Cores with Gold Nanorod Optical Triggers
Nanoscale, 8, pp. 11851–11861 (2016)
DOI: 10.1039/C5NR09235C -
Probing the twisted structure of sickle hemoglobin fibers via coarse-grained molecular simulations
Biophysical Journal, 110, pp. 2085–2093 (2016)
DOI: 10.1016/j.bpj.2016.04.002
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Molecular Mechanisms of Hematin Crystallization from Organic Solvent
Crystal Growth & Design, 15, pp. 5535–5542 (2015)
DOI: 10.1021/acs.cgd.5b01157 -
Lack of Dependence of the Sizes of the Mesoscopic Protein Clusters on Electrostatics
Biophysical Journal, 109, pp. 1959–1968 (2015)
DOI: 10.1016/j.bpj.2015.09.025 -
Lipid or aqueous medium for hematin crystallization?
CrystEngComm, 17, pp. 7790–7800 (2015)
DOI: 10.1039/C5CE01178G -
Differential dynamic microscopy of weakly scattering and polydisperse protein-rich clusters
Physical Review E, 92, pp. 042712 (2015)
DOI: 10.1103/PhysRevE.92.042712 -
The free heme concentration in healthy human erythrocytes
Blood Cells, Molecules and Diseases, 55, pp. 402–409 (2015)
DOI: 10.1016/j.bcmd.2015.09.003 -
Thermodynamic mechanism of free heme action on sickle cell hemoglobin polymerization
AIChE Journal, 61, pp. 2861–2170 (2015)
DOI: 10.1002/aic.14867 -
Do Protein Crystals Nucleate within Dense Liquid Clusters?
Acta Crystallographica Section F, 71, pp. 815–822 (2015)
DOI: 10.1107/S2053230X1500899 -
Recent advances in the understanding of two-step nucleation of protein crystals
Faraday Discussions, 179, pp. 27–40 (2015)
DOI: 10.1039/C4FD00217B -
Nucleation in complex multi-component and multi-phase systems: general discussion
Faraday Discussions, 179, pp. 503–542 (2015)
DOI: 10.1039/C5FD90039E -
Molecular self-assembly and clustering in nucleation processes: general discussion
Faraday Discussions, 179, pp. 155–197 (2015)
DOI: 10.1039/C5FD90036K -
Solvent and additive interactions as determinants in the nucleation pathway: general discussion
Faraday Discussions, 179, pp. 383–420 (2015)
DOI: 10.1039/C5FD90038G -
Time and space resolved methods: general discussion
Faraday Discussions, 179, pp. 247–267 (2015)
DOI: 10.1039/C5FD90037A
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Growth of Large Hematin Crystals in Biomimetic Solutions
Crystal Growth & Design, 14, pp. 2123–2127 (2014)
DOI: 10.1021/cg5002682 -
Thermodynamics of protein crystallization: a dialogue with Professor Sunagawa
Journal of the Japanese Association for Crystal Growth, 41, pp. 18–20 (2014)
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Nucleation precursors in protein crystallization
Acta Crystallographica Section F, 70, pp. 271–282 (2014)
DOI: 10.1107/S2053230X14002386
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Hematin crystallization from aqueous and organic solvents
Journal of Chemical Physics, 139, pp. 121911 (2013)
DOI: 10.1063/1.4816106 -
Design of gastight picoliter reactors allowing in situ optical observation
Journal of Micromechanics and Microengineering, 23, pp. 105003 (2013)
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Phase diagrams and kinetics of phase transitions in protein solutions
Journal of Physics: Condensed Matter, 24, pp. 193101 (2012)
DOI: 10.1088/0953-8984/24/19/193101 -
Control of the nucleation of sickle cell hemoglobin polymers by free hematin
Faraday Discussions, 159, pp. 87–104 (2012)
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Ostwald-like ripening of the anomalous mesoscopic clusters in protein solutions
Journal of Physical Chemistry B, 116, pp. 10657–10665 (2012)
DOI: 10.1021/jp303316s -
Does solution viscosity scale the rate of protein aggregation?
Journal of Physical Chemistry Letters, 3, pp. 1258–1263 (2012)
DOI: 10.1021/jz300459n -
Anisotropy of the Coulomb interaction between folded proteins: Consequences for mesoscopic aggregation of lysozyme
Biophysical Journal, 102, pp. 1934–1943 (2012)
DOI: 10.1016/j.bpj.2012.03.025
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The use of dynamic light scattering and Brownian microscopy to characterize protein aggregation
Review of Scientific Instruments, 82, pp. 053106 (2011)
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Nucleation of Protein Condensed Phases
Reviews in Chemical Engineering, 27, pp. 1–13 (2011)
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The two-step mechanism of nucleation of crystals in solution
Nanoscale, 2, pp. 2346–2357 (2010)
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Free heme and the polymerization of sickle cell hemoglobin
Biophysical Journal, 99, pp. 1976–1985 (2010)
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The origin of anomalous mesoscopic phases in protein solutions
Journal of Physical Chemistry B, 114, pp. 7620–7630 (2010)
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Interactions of hemin with a model erythrocyte membrane
Journal of Physical Chemistry B, 114, pp. 4529–4535 (2010)
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Nucleation
Crystal Growth and Design, 10, pp. 5007–5019 (2010)
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Phase transitions in protein solutions
Soft Matter, 6, pp. 5254–5272 (2010)
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Free heme in micromolar amounts enhances the attraction between sickle cell hemoglobin molecules
Biopolymers, 91, pp. 1108–1116 (2009)
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Localized generation of attoliter protein solution droplets by electrofocused liquid-liquid separation
Journal of Physical Chemistry B, 113, pp. 7340–7346 (2009)
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Metastable mesoscopic phases in concentrated protein solutions
Annals of the New York Academy of Sciences, 1161, pp. 377–386 (2009)
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Viscoelasticity in homogeneous protein solutions
Physical Review Letters, 102, pp. 058101 (2009)
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Chiral and achiral mechanisms of regulation of calcite crystallization
Crystal Growth and Design, 9, pp. 127–135 (2009)
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Chemical engineers and the fundamental understanding of human disease
AIChE Journal, 54, pp. 2508–2515 (2008)
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Phase separation and crystallization of hemoglobin C in transgenic mouse and human erythrocytes
Biophysical Journal, 95, pp. 4025–4033 (2008)
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Determination of the transition-state entropy for aggregation suggests how the growth of sickle cell hemoglobin polymers can be slowed
Journal of Molecular Biology, 377, pp. 882–888 (2008)
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What determines the rate of growth of crystals from solution?
Crystal Growth and Design, 7, pp. 2796–2810 (2007)
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What is the molecular-level role of the solution components in protein crystallization?
Crystal Growth and Design, 7, pp. 2239–2246 (2007)
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Two-step mechanism of homogeneous nucleation of sickle cell hemoglobin polymers
Biophysical Journal, 92, pp. 902–913 (2007)
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Sickle-cell haemoglobin polymerization: is it the primary pathogenic event of sickle-cell anaemia?
British Journal of Haematology, 139, pp. 173–184 (2007)
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Metastable liquid clusters in super- and undersaturated protein solutions
Journal of Physical Chemistry B, 111, pp. 3106–3114 (2007)
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Metastable mesoscopic clusters in solutions of sickle cell hemoglobin
Biophysical Journal, 92, pp. 267–277 (2007)
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The kinetics of nucleation and growth of sickle cell hemoglobin fibers
Journal of Molecular Biology, 365, pp. 425–439 (2007)
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Violation of Gibbs’s definition of phase for protein solutions
Journal of the Association for Crystal Growth, 34, pp. 56–62 (2007)
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Nucleation of protein crystals under the influence of solution shear flow
Annals of the New York Academy of Sciences, 1077, pp. 214–231 (2006)
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Corresponding-states laws for protein solutions
Journal of Physical Chemistry B, 110, pp. 17638–17644 (2006)
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Multiple extrema in the intermolecular potential and the phase diagram of protein solutions
Physical Review E, 73, pp. 061917 (2006)
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A fast response mechanism for insulin storage in crystals may involve kink generation by association of 2D clusters
Proceedings of the National Academy of Sciences USA, 103, pp. 1681–1686 (2006)
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Entropy and surface engineering in protein crystallization
Acta Crystallographica Section D, 62, pp. 116–124 (2006)
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Spinodal for the solution to crystal phase transformation
Journal of Chemical Physics, 123, pp. 014904 (2005)
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Kinetics of two-step nucleation of crystals
Journal of Chemical Physics, 122, pp. 244706 (2005)
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Nucleation of ordered solid phases of proteins via a disordered high-density state: phenomenological approach
Journal of Chemical Physics, 122, pp. 174905 (2005)
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Enhancement and suppression of protein crystal nucleation due to electrically-driven convection
Journal of Crystal Growth, 275, pp. 1527–1532 (2005)
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Dense liquid droplets as a step source for the crystallization of lumazine synthase
Journal of Crystal Growth, 275, pp. 1409–1416 (2005)
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Two-step mechanism for the nucleation of crystals from solution
Journal of Crystal Growth, 275, pp. 65–76 (2005)
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Steps in solution growth: dynamics of kinks, bunching and turbulence
Journal of Crystal Growth, 275, pp. 1–18 (2005)
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A metastable prerequisite for the growth of lumazine synthase crystals
Journal of the American Chemical Society, 127, pp. 3433–3438 (2005)
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The aspect ratio of potassium di-deuterium phosphate (DKDP) crystals
Crystal Growth and Design, 5, pp. 105–110 (2005)
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Dense liquid precursor for the nucleation of ordered solid phases from solution
Crystal Growth and Design, 4, pp. 671–685 (2004)
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Step and kink dynamics in inorganic and protein crystallization
MRS Bulletin, 29, pp. 927–934 (2004)
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Mechanisms of in cubo growth and defect formation of three-dimensional bacteriorhodopsin crystals
Journal of Molecular Biology, 343, pp. 1243–1254 (2004)
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Smooth transition from metastability to instability in phase separating protein solutions
Journal of Chemical Physics, 121, pp. 7505–7512 (2004)
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Crystallization mechanisms of hemoglobin C in the R-state
Biophysical Journal, 87, pp. 2621–2629 (2004)
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Liquid-liquid separation in hemoglobins: distinct aggregation mechanisms of the b6 mutants
Biophysical Journal, 86, pp. 1702–1712 (2004)
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Interplay of impurities and solution flow as determinants of step patterns dynamics
Physical Review E, 69, pp. 011604 (2004)
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Mechanisms of homogeneous nucleation of polymers of sickle cell anemia hemoglobin in deoxy-state
Journal of Molecular Biology, 336, pp. 43–59 (2004)
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Thermodynamics of the hydrophobicity in crystallization of insulin
Biophysical Journal, 85, pp. 3935–3942 (2003)
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Capillarity effects on crystallization kinetics: insulin
Journal of the American Chemical Society, 125, pp. 11684–11693 (2003)
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Stable equidistant step trains during crystallization of insulin
Physical Review Letters, 90, pp. 225503 (2003)
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Thermodynamic functions of concentrated protein solutions from phase equilibria
Journal of Physical Chemistry B, 107, pp. 3921–3926 (2003)
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Dissipating step bunches during crystallization under transport control
Physical Review E, 67, pp. 031606 (2003)
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On the methods of determination of homogeneous nucleation rates of protein crystals
Colloids and Surfaces A, 215, pp. 125–130 (2003)
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Diffusion-limited kinetics of the solution-solid phase transition of molecular substances
Proceedings of the National Academy of Sciences USA, 100, pp. 792–796 (2003)
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Self-Assembly of Apoferritin Molecules into Crystals: Thermodynamics of Molecular Level Processes
Progress in Crystal Growth and Characterization of Materials, 45, pp. 175–199 (2002)
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Spatio-temporal step patterns during crystal growth in a transport controlled system
Journal of Physical Chemistry, 106, pp. 11800–11804 (2002)
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Differential phase-shifting interferometry for in situ surface characterization during solution growth of crystals
Review of Scientific Instruments, 73, pp. 3540–3545 (2002)
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Step bunching in a diffusion-controlled system: phase-shifting interferometry investigation of ferritin
Acta Crystallographica Section D, 58, pp. 1622–1627 (2002)
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Solvent entropy contribution to the free energy of protein crystallization
Acta Crystallographica Section D, 58, pp. 1611–1616 (2002)
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Phase-shifting interferometry for the study of the step dynamics during crystallization of proteins
Crystal Growth and Design, 2, pp. 381–385 (2002)
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Evidence for the surface diffusion mechanism of solution crystallization from molecular-level observations
Physical Review E, 66, pp. 021606 (2002)
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Step Bunching in KDP Crystal Growth: Phenomenology
Journal of Materials Research, 17, pp. 2059–2065 (2002)
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Intermolecular Interactions, Nucleation and Thermodynamics of Crystallization of Hemoglobin C
Biophysical Journal, 83, pp. 1147–1156 (2002)
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Characteristic lengthscales of step bunching in KDP crystal growth: in-situ differential phase-shifting interferometry study
Journal of Crystal Growth, 237–239, pp. 1818–1824 (2002)
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Liquid-liquid separation in solutions of normal and sickle cell hemoglobin
Proceedings of the National Academy of Sciences USA, 99, pp. 8479–8483 (2002)
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Temperature-independent solubility and interactions between apoferritin monomers and dimers in solution
Journal of Crystal Growth, 232, pp. 27–29 (2001)
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Real time, in-situ, monitoring of apoferritin crystallization and defect formation with molecular resolution
Journal of Crystal Growth, 232, pp. 188–194 (2001)
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Nucleation of protein crystals: critical nuclei, phase behavior, and control pathways
Journal of Crystal Growth, 232, pp. 63–76 (2001)
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Are protein crystallization mechanisms relevant to understanding and control of polymerization of deoxyhemoglobin S?
Journal of Crystal Growth, 232, pp. 368–375 (2001)
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Molecular mechanisms of microheterogeneity-induced defect formation in ferritin crystallization
Proteins, 43, pp. 343–352 (2001)
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Direct observation of nucleus structure and nucleation pathways
Journal of the American Chemical Society, 123, pp. 1080–1089 (2001)
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Lower incorporation of impurities in ferritin crystals by suppression of convection: modeling results
Crystal Growth and Design, 1, pp. 73–79 (2001)
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Dynamics of layer growth in protein crystallization
Chemical Reviews, 100, pp. 2061–2089 (2000)
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Molecular-level thermodynamic and kinetic parameters for the self-assembly of apoferritin molecules into crystals
Journal of Molecular Biology, 303, pp. 667–678 (2000)
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Differential pathways in oxy and deoxy HbC aggregation/crystallization
Proteins, 42, pp. 99–107 (2000)
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Quasi-planar nucleus structure in apoferritin crystallisation
Nature, 406, pp. 494–497 (2000)
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Molecular mechanisms of crystallization and defect formation
Physical Review Letters, 85, pp. 353–356 (2000)
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Control of protein crystal nucleation around the metastable liquid-liquid phase boundary
Proceedings of the National Academy of Sciences USA, 97, pp. 6277–6281 (2000)
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Distribution coefficients of protein impurities in ferritin and lysozyme crystals. Self-purification in microgravity
Journal of Crystal Growth, 211, pp. 149–156 (2000)
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Interactions and aggregation of apoferritin molecules in solution: Effects of added electrolyte
Biophysical Journal, 78, pp. 2060–2069 (2000)
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Evidence for non-DLVO hydration interactions in solutions of the protein apoferritin
Physical Review Letters, 84, pp. 1339–1342 (2000)
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Are nucleation kinetics of protein crystals similar to those of liquid droplets?
Journal of the American Chemical Society, 122, pp. 156–163 (2000)
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Finite-amplitude instability in growth step trains with overlapping step supply fields
Physical Review E, 59, pp. 3155–3164 (1999)
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Lower dimer impurity incorporation may result in higher perfection of HEWL crystals grown in microgravity. A case study
Journal of Crystal Growth, 196, pp. 623–637 (1999)
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Nonlinear dynamics of layer growth and consequences for protein crystal perfection
Journal of Crystal Growth, 196, pp. 261–275 (1999)
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Protein crystal growth – microgravity aspects
Advances in Space Research, 24, pp. 1231–1240 (1999)
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Intrinsic stability of concentration field in diffusion limited growth and its effects on crystallization
Physical Review E, 60, pp. 1901–1905 (1999)
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Direct determination of the nucleation rates of protein crystals
Journal of Physical Chemistry, 103, pp. 10965–10971 (1999)
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Miniaturized scintillation technique for protein solubility determinations
Review of Scientific Instruments, 70, pp. 2845–2849 (1999)
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Effects of convective solute and impurity transport on protein crystal growth
Journal of Physical Chemistry, 102, pp. 5208–5216 (1998)
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Intrinsic kinetics fluctuations as cause of growth inhomogeneity in protein crystals
Physical Review E, 57, pp. 6979–6981 (1998)
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Increased stability in crystal growth kinetics in response to bulk transport enhancement
Physical Review Letters, 80, pp. 2654–2656 (1998)
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Protein crystal growth under forced solution flow: experimental setup and general response of lysozyme
Journal of Crystal Growth, 186, pp. 251–261 (1998)
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Effects of microheterogeneity on hen egg white lysozyme crystallization
Acta Crystallographica D, 54, pp. 226–236 (1998)
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A rationale for system-dependent advantages and disadvantages of solution crystal growth at low gravity
Microgravity Science and Technology, 10, pp. 29–35 (1997)
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X-ray topography of tetragonal lysozyme grown by the temperature controlled technique
Acta Crystallographica D, 53, pp. 588–595 (1997)
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Unsteady crystal growth due to step-bunch cascading
Physical Review E, 55, pp. 3202–3214 (1997)
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Nonlinear response of layer growth dynamics in the mixed kinetics-bulk transport regime
Physical Review E, 54, pp. 6650–6660 (1996)
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Nucleation and crystallization of globular proteins – What do we know and what is missing?
Journal of Crystal Growth, 167, pp. 1–27 (1996)
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Repartitioning of NaCl and protein impurities in lysozyme crystallization
Acta Crystallographica D, 52, pp. 785–798 (1996)
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Heterogeneity determination and purification of commercial hen egg white lysozyme
Acta Crystallographica D, 52, pp. 776–784 (1996)
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Facet morphology response to non-uniformities in nutrient and impurity supply. II. Numerical modeling
Journal of Crystal Growth, 158, pp. 552–559 (1996)
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Dependence of lysozyme growth kinetics on step sources and impurities
Journal of Crystal Growth, 158, pp. 540–551 (1996)
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Facet morphology response to non-uniformities in nutrient and impurity supply. I. Experiments and interpretation
Journal of Crystal Growth, 156, pp. 267–278 (1995)
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High-resolution interferometric technique for in-situ studies of crystal growth morphologies and kinetics
Journal of Crystal Growth, 146, pp. 289–296 (1995)
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Growth processes of protein crystals revealed by laser Michelson interferometry investigation
Acta Crystallographica D, 51, pp. 207–219 (1995)
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Laser Michelson Interferometry investigation of protein crystal growth
Journal of Crystal Growth, 130, pp. 317–320 (1993)
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Elementary growth mechanism of dipyramid ADP faces
Ferroelectrics, 142, pp. 145–152 (1993)
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Elementary growth kinetics of silver electrocrystallization
Journal of Crystal Growth, 125, pp. 229–236 (1992)
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Interstep interaction in solution growth; (101) ADP face
Journal of Crystal Growth, 121, pp. 643–655 (1992)
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The effect of temperature on step motion; (101) ADP face
Journal of Crystal Growth, 121, pp. 44–52 (1992)
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Growth kinetics irregularities due to changed dislocation source activity; (101) ADP face
Journal of Crystal Growth, 119, pp. 248–260 (1992)
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Dissolution morphology and kinetics of (101) ADP face; mild etching of possible surface defects
Journal of Crystal Growth, 102, pp. 706–716 (1990)
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Kinetics of growth of (101) faces of NH4H2PO4 crystals from aqueous solutions
Soviet Physics – Crystallography, 32, pp. 584–587 (1987)